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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

《医学前沿（英文）》 2009年 第3卷 第1期   页码 20-25 doi: 10.1007/s11684-009-0006-9

摘要： The interaction by co-stimulatory molecules 4-1BB and 4-1BB ligand (4-1BBL) plays an important role in the activation, proliferation and differentiation of T lymphocytes. The function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapy efforts. In this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL in lymphocyte activation and tumor suppression was investigated. The plasmid p4-1BBL containing the full length of mouse 4-1BBL cDNA sequence was constructed, and the plasmid was transfected into baby hamster kidney (BHK) cells and murine muscle cells by means of lipofectin-mediated or naked plasmid DNA injection into the muscle directly. The study demonstrated that the molecule 4-1BBL expressed by BHK cells could enhance the proliferation and cytotoxicity of lymphocytes, and it could increase the expression level of IL-2 and IFN-γ. The treatment with plasmid p4-1BBL revealed that the number of CD8 T cells in the peri-tumoral tissue increased markedly, and the growth rate of the tumor was significantly lower than that of control group. These findings suggest that expression of 4-1BBL by normal cells in the tumor microenvironment can enhance the proliferation and other functions of T lymphocytes. This therapeutic method may provide a promising approach for tumor immunotherapy.

关键词： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

《医学前沿（英文）》   页码 805-822 doi: 10.1007/s11684-023-1025-7

摘要： Immunotherapies based on immune checkpoint blockade (ICB) have significantly improved patient outcomes and offered new approaches to cancer therapy over the past decade. To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapy. Blockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers, however, a large subset of refractory patients presents poor responsiveness to ICB therapy; and the underlying mechanism remains elusive. Recently, numerous studies have revealed that metabolic reprogramming of tumor cells restrains immune responses by remodeling the tumor microenvironment (TME) with various products of metabolism, and combination therapies involving metabolic inhibitors and ICIs provide new approaches to cancer therapy. Nevertheless, a systematic summary is lacking regarding the manner by which different targetable metabolic pathways regulate immune checkpoints to overcome ICI resistance. Here, we demonstrate the generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1, and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting tumor metabolic pathways and immune checkpoints.

关键词： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic strategies    

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Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4

《化学科学与工程前沿（英文）》 2022年 第16卷 第7期   页码 1090-1100 doi: 10.1007/s11705-021-2091-5

摘要： Twenty six novel pyrimidin-4-amine derivatives containing the 1,2,4-oxadiazole motif were synthesized. Their chemical structures were confirmed by 1H nuclear magnetic resonance (NMR), 13C NMR, and high-resolution mass spectrography. The insecticidal activity results indicated that some of them possessed excellent insecticidal activity (100%) against Mythimna separate, especially for compounds 6d, 6f, 6o, 6w, 6y and 6z. These compounds exhibited no activity against the insects Aphis medicagini and Tetranychus cinnabarinus. The structure- insecticidal activity relationships are discussed. Density functional theory analysis can potentially be used to design more active compounds. These results provide useful insecticide design information for further optimization.

关键词： synthesis     pyrimidin-4-amine derivatives     1     2     4-oxadiazole     insecticidal activity     structure-activity relationship    

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用以产生高纯度涡旋波束的宽带圆极化透射阵 Correspondence

邱靓婕1,2,3,4,李秀萍1,2,3,4,齐紫航1,2,3,4,赵文禹1,2,3,4,黄雨菡5

《信息与电子工程前沿（英文）》 2023年 第24卷 第6期   页码 927-934 doi: 10.1631/FITEE.2200539

摘要： 亚波长结构以及双谐振特性确保了透射单元在28.4%的1-dB透射带宽内具有稳定的相移能力。基于此，加工测试了一款由喇叭天线馈电的方形口径透射阵。得益于蜂窝状布阵方式，所设计的透射阵可在28.5 GHz到38 GHz的宽带范围中辐射l=–1且模态纯度高于0.93的涡旋波束。测试的峰值增益为22.3 dBic，3-dB轴比带宽为27.6%。

关键词： 轨道角动量；涡旋波束；透射阵；宽带；高纯度    

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Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones

Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO

《化学科学与工程前沿（英文）》 2009年 第3卷 第2期   页码 186-191 doi: 10.1007/s11705-009-0004-0

摘要： 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones and were synthesized in 41%-67% yield by using microwave-assisted one-pot protocol. The structures of the new compounds , , , , , , and - were confirmed by IR, NMR, MS, and elemental analysis. The antimicrobial activities of the compounds against pv. lachrymans (Smith et Bryan) Young, Dye & Wilkie, Pers., and Blum. were examined. Some of the compounds showed good antifungical activity against Blum.

关键词： microwave-assisted synthesis     naphthyl     thiazolidin-4-one     antimicrobial    

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Surface modification by ligand growth strategy for dense copper bismuth film as photocathode to enhance

《能源前沿（英文）》 doi: 10.1007/s11708-023-0893-5

摘要： Hydrogen production from photoelectrochemical (PEC) water splitting has been regarded as a promising way to utilize renewable and endless solar energy. However, semiconductor film grown on photoelectrode suffers from numerous challenges, leading to the poor PEC performance. Herein, a straightforward sol-gel method with the ligand-induced growth strategy was employed to obtain dense and homogeneous copper bismuthate photocathodes for PEC hydrogen evolution reaction. By various characterizations, it was found that the nucleation and surface growth of CuBi2O4 layer induced by 2-methoxyethanol ligand (2-CuBi2O4) demonstrated a decent crystallinity and coverage, as well as a large grain size and a low oxygen vacancy concentration, leading to the good ability of light absorption and carrier migration. Consequently, under simulated sunlight irradiation (AM1.5G, 100 mW/cm2), the 2-CuBi2O4 photocathode achieved an enhanced photocurrent density of −1.34 mA·cm−2 at 0.4 V versus the reversible hydrogen electrode and a promising applied bias photon-to-current efficiency of 0.586%. This surface modification by ligand growth strategy will shed light on the future design of advanced photoelectrodes for PEC water splitting.

关键词： copper bismuthate     photocathode     ligand growth strategy     dense film     PEC    

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新闻媒体眼中的中国：新冠肺炎疫情下的案例研究 Research Article

黄宏1,2,3,4,陈哲学1,2,3,4,石宣化1,2,3,4,王晨旭1,2,3,4,何泽鹏1,2,3,4,金海1,2,3,4,张明新5,李宗亚5

《信息与电子工程前沿（英文）》 2021年 第22卷 第11期   页码 1443-1457 doi: 10.1631/FITEE.2000689

摘要： 我们主要想回答3个问题：（1）新冠肺炎疫情期间，国际媒体关注的焦点是什么？（2）媒体报道中国时的立场是什么？（3）媒体谈论中国时的态度是什么？例如，新冠肺炎疫情期间，国际媒体更加关注中国民生；在3月和4月，“中国疫苗进展”“特定药物和治疗”“美国病毒爆发”成为媒体最常见话题；在新闻态度方面，古巴、马来西亚、委内瑞拉对中国持正面态度，而法国、加拿大

关键词： 国家形象；新冠肺炎；主题挖掘；实体；新闻立场；情感    

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基于半导体纳米晶体的神经突触器件 Review

步明轩1,2,王越1,2,尹蕾1,2,童周禹1,2,张懿强3,杨德仁1,2,4,5,皮孝东1,2,4,5

《信息与电子工程前沿（英文）》 2022年 第23卷 第11期   页码 1579-1601 doi: 10.1631/FITEE.2100551

摘要：

近年来，人们对信息处理的需求日益增长，脑启发式神经形态器件得到了广泛的关注。突触器件作为一类重要的神经形态器件，在短短几年内迅速升温。在用于制备突触器件的各种材料中，半导体纳米晶体（NCs）因其优异的电学和光学性能而成为首选材料之一。本综述论文首先介绍了基于半导体纳米晶体的突触器件的研究背景及半导体纳米晶体的基本性质。然后，根据器件有源层所用纳米晶体种类的不同，分类介绍了基于纳米晶体的突触器件的最新研究进展。最后，讨论了基于半导体纳米晶体的突触器件目前仍面临的问题和挑战。

关键词： 半导体纳米晶体；突触器件；神经形态计算    

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Highly selective detection of copper(II) by a “ligand-free” conjugated copolymer in nucleophilic solvents

Weixing Deng, Pengfei Sun, Quli Fan, Lei Zhang, Tsuyoshi Minami

《化学科学与工程前沿（英文）》 2020年 第14卷 第1期   页码 105-111 doi: 10.1007/s11705-019-1791-6

摘要： The synthesis of -cyclohexyl carbamate-attached fluorene- -phenylene copolymer (PFPNCC) and the use of PFPNCC as a “ligand-free” fluorescent chemosensor for Cu(II) are described. Addition of Cu(II) can efficiently quench the fluorescence of PFPNCC in nucleophilic solvents such as DMF and DMSO, but not in low nucleophilic solvents such as 1,4-dioxane and THF. Ultraviolet-visible spectra of the mixture of the conjugated polymer and Cu(II) indicate the presence of a reduced Cu(I) ion in the solution. Furthermore, fluorescence recovery of PFPNCC observed at low temperature suggests that the quenching and reducing mechanism is most probably due to a photo-induced electron transfer from excited PFPNCC to Cu(II). Our findings provide a novel strategy for highly selective conjugated polymer-based chemosensors for various target analytes, albeit “ligand-free”.

关键词： ligand-free     fluorescent chemosensor     copper     photo-induced electron transfer    

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基于二硫化钛可饱和吸收体的被动锁模掺铒光纤激光器 Research Articles

尚新新1,3,4,郭林广1,3,4,张华年2,李登旺1,3,4,岳庆炀1,3,4

《信息与电子工程前沿（英文）》 2021年 第22卷 第5期   页码 615-766 doi: 10.1631/FITEE.2000341

摘要： 本文采用液相剥离法和旋涂法合成调制深度为5.08%、饱和强度为10.62 MW/cm2的二硫化钛聚乙烯醇薄膜型可饱和吸收体。由于二硫化钛可饱和吸收体具有很强的非线性饱和吸收特性，在掺铒锁模光纤激光器中观测到两种类型的光孤子。当泵浦功率达到67.3 mW时，产生重复率为1.716 MHz、脉宽为6.57 ps的传统锁模脉冲串，其输出光谱中心为1556.98 nm、半高全宽为0.466 nm，且有明显对称的Kelly边带。通过调整偏振控制器，得到另一种锁模脉冲，在517.2 mW泵浦功率下，其最大输出功率为3.92 mW，脉冲能量为2.28 nJ。实验证明层状二维材料二硫化钛具有优异的非线性饱和吸收特性，在超快光子学领域具有广阔应用前景。

关键词： 光纤激光器；被动锁模；可饱和吸收体；二硫化钛    

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Synthesis of vinylferrocene and the ligand-exchange reaction between its copolymer and carbon nanotubes

Ran SHI,Hai WANG,Ping TANG,Yuezhen BIN

《化学科学与工程前沿（英文）》 2014年 第8卷 第2期   页码 171-178 doi: 10.1007/s11705-014-1428-8

摘要： To improve the dispersibility of carbon nanotubes (CNTs), poly(vinylferrocene- -styrene) (poly(Vf- -St)), was grafted onto the surface of CNTs by a ligand-exchange reaction. Poly(Vf- -St) was obtained by a radical copolymerization reaction using styrene and vinylferrocene as the monomers. The vinylferrocene was synthesized from ferrocene via a Friedel-Crafts acylation. The molecular weight, molecular weight distribution, and amount of Vf in the poly(Vf- -St) were 1.32 × 10 , 1.69 and 17.6% respectively. The degree of grafting of the copolymer onto the CNTs surface was calculated from thermogravimetric analysis and varied from 27.1% to 79.7%. The addition of the poly(Vf- -St) greatly promoted the dispersibility of the modified CNTs in anhydrous alcohol. The electrical conductivity of composites prepared from the polymer-grafted CNTs and copolymer (acrylonitrile, 1,3-butadiene and styrene, ABS) strongly depended on the degree of grafting. These results show that the amount of polymer grafted onto the surface of CNTs can be controlled and that the electrical properties of composites prepared with these grafted polymers can be tuned.

关键词： vinylferrocene     poly (Vf-co-St)     CNTs     dispersibility    

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空间衍射望远系统发展现状 Review Article

赵维1,3,4,王新1,刘华‡2,4,陆子凤2,4,卢振武5

《信息与电子工程前沿（英文）》 2020年 第21卷 第6期   页码 809-962 doi: 10.1631/FITEE.1900529

摘要： 基底微结构制作的薄膜衍射光学元件具备超轻质量（面密度小于0.1 kg/m2）和宽松表面形状公差（厘米级表面精度需求）两个重要特性，将其作为大口径望远镜的主镜可实现超大口径，超轻量化，同时降低发射成本。本文对国内外基于衍射光学的空间大口径望远系统的研究进展进行归纳和总结。首先阐述衍射望远系统的成像理论与组成结构，然后介绍衍射望远系统研究进展，最后总结衍射技术作为未来高分辨率空间侦查系统的发展趋势，提出我国应着重开展的相关工作。

关键词： 薄膜衍射光学元件；衍射望远系统；超大口径    

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转录因子HNF1A、HNF4A和FOXA2调节肝细胞蛋白质N-糖基化 Article

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

《工程（英文）》 2024年 第32卷 第1期   页码 58-69 doi: 10.1016/j.eng.2023.09.019

摘要：

Hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkhead box protein A2 (FOXA2) are key transcription factors that regulate a complex gene network in the liver, creating a regulatory transcriptional loop. The Encode and ChIP-Atlas databases identify the recognition sites of these transcription factors in many glycosyltransferase genes. Our in silico analysis of HNF1A, HNF4A, and FOXA2 binding to the 10 candidate glyco-genes studied in this work confirms a significant enrichment of these transcription factors specifically in the liver. Our previous studies identified HNF1A as a master regulator of fucosylation, glycan branching, and galactosylation of plasma glycoproteins. Here, we aimed to functionally validate the role of the three transcription factors on downstream glyco-gene transcriptional expression and the possible effect on glycan phenotype. We used the state-of-the-art clustered regularly interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9) molecular tool for the downregulation of the HNF1A, HNF4A, and FOXA2 genes in HepG2 cells—a human liver cancer cell line. The results show that the downregulation of all three genes individually and in pairs affects the transcriptional activity of many glyco-genes, although downregulation of glyco-genes was not always followed by an unambiguous change in the corresponding glycan structures. The effect is better seen as an overall change in the total HepG2 N-glycome, primarily due to the extension of biantennary glycans. We propose an alternative way to evaluate the N-glycome composition via estimating the overall complexity of the glycome by quantifying the number of monomers in each glycan structure. We also propose a model showing feedback loops with the mutual activation of HNF1A–FOXA2 and HNF4A–FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.

关键词： Clustered regularly interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9)     Epigenetics     Hepatocyte nuclear factor 1 alpha (HNF1A)     Hepatocyte nuclear factor 4 alpha (HNF4A)     Forkhead box protein A2 (FOXA2)     N-glycosylation     HepG2 cells    

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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

《化学科学与工程前沿（英文）》 2009年 第3卷 第3期   页码 305-309 doi: 10.1007/s11705-009-0021-z

摘要： A series of new benzimidazole derivatives were designed and synthesized. Their chemical structures were testified by H NMR, infrared spectroscopy (IR), mass spectrography (MS), and elemental analysis. Their potent antiviral properties indicated the prospect of new drugs. Compound , , , , , , and were identified as novel antivirus with much better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B in VERO cells.

关键词： benzimidazole     coxsackie virus B3     antiviral properties    

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Effect of ligand chain length on hydrophobic charge induction chromatography revealed by molecular dynamics

Lin ZHANG, Yan SUN

《化学科学与工程前沿（英文）》 2013年 第7卷 第4期   页码 456-463 doi: 10.1007/s11705-013-1357-y

摘要： Hydrophobic charge induction chromatography (HCIC) is a mixed-mode chromatography which is advantageous for high adsorption capacity and facile elution. The effect of the ligand chain length on protein behavior in HCIC was studied. A coarse-grain adsorbent pore model established in an earlier work was modified to construct adsorbents with different chain lengths, including one with shorter ligands (CL2) and one with longer ligands (CL4). The adsorption, desorption, and conformational transition of the proteins with CL2 and CL4 were examined using molecular dynamics simulations. The ligand chain length has a significant effect on both the probability and the irreversibility of the adsorption/desorption. Longer ligands reduced the energy barrier of adsorption, leading to stronger and more irreversible adsorption, as well as a little more unfolding of the protein. The simulation results elucidated the effect of the ligand chain length, which is beneficial for the rational design of adsorbents and parameter optimization for high-performance HCIC.

关键词： adsorption     desorption     irreversibility     protein conformational transition     molecular dynamics simulation    

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标题 作者 时间 类型 操作

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

期刊论文

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

期刊论文

Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4

期刊论文

用以产生高纯度涡旋波束的宽带圆极化透射阵

邱靓婕1,2,3,4,李秀萍1,2,3,4,齐紫航1,2,3,4,赵文禹1,2,3,4,黄雨菡5

期刊论文

Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones

Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO

期刊论文

Surface modification by ligand growth strategy for dense copper bismuth film as photocathode to enhance

期刊论文

新闻媒体眼中的中国：新冠肺炎疫情下的案例研究

黄宏1,2,3,4,陈哲学1,2,3,4,石宣化1,2,3,4,王晨旭1,2,3,4,何泽鹏1,2,3,4,金海1,2,3,4,张明新5,李宗亚5

期刊论文

基于半导体纳米晶体的神经突触器件

步明轩1,2,王越1,2,尹蕾1,2,童周禹1,2,张懿强3,杨德仁1,2,4,5,皮孝东1,2,4,5

期刊论文

Highly selective detection of copper(II) by a “ligand-free” conjugated copolymer in nucleophilic solvents

Weixing Deng, Pengfei Sun, Quli Fan, Lei Zhang, Tsuyoshi Minami

期刊论文

基于二硫化钛可饱和吸收体的被动锁模掺铒光纤激光器

尚新新1,3,4,郭林广1,3,4,张华年2,李登旺1,3,4,岳庆炀1,3,4

期刊论文

Synthesis of vinylferrocene and the ligand-exchange reaction between its copolymer and carbon nanotubes

Ran SHI,Hai WANG,Ping TANG,Yuezhen BIN

期刊论文

空间衍射望远系统发展现状

赵维1,3,4,王新1,刘华‡2,4,陆子凤2,4,卢振武5

期刊论文

转录因子HNF1A、HNF4A和FOXA2调节肝细胞蛋白质N-糖基化

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

期刊论文

Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

期刊论文

Effect of ligand chain length on hydrophobic charge induction chromatography revealed by molecular dynamics

Lin ZHANG, Yan SUN

期刊论文